lecture today was good.. and so was the lab amazingly... maybe now i'm more wired up for the block....
anyway... my Pooh Report..
Name of Famous Person (& life-time dates if known): Winnie-the-Pooh
What did this person achieve that makes her/him noteworthy? (max 30 words ) He is a popular character in a series of books that sold over 20 million copies and was translated into 32 languages. His total royalties amount to $100 million.
What illness did the person have or what was the cause of death? (max 10 words) ADHD, OCD, binge eating disorder, “shaken bear” syndrome.
Describe the manifestation of the illness/cause of death. (max 30 words) Obsesses over amount of honey consumed, struggles with repetitive counting of honey pots, consumes large amounts of honey impulsively, short term memory, lack of concentration.
Provide, in terms of present day knowledge, a description of the molecular/cellular processes that gave rise to the illness/cause of death. Your description must focus on the underlining biological change and should not include clinical detail. (max 250 words)
In OCD, not only is white matter of the brain significantly decreased, there seems to be a short circuit in one of the essential pathways in the brain, which involve the orbital-frontal cortex [OFC](the part of the brain that notices if something is wrong), the caudate nucleus (the intermediate that regulates signals between the OFC and the thalamus) and the thalamus (the part of the brain that directs signals from other parts of the brain to places where they can be interpreted). In a normal context, the caudate nucleus suppresses the signals from the OFC preventing hyperactivity of the thalamus. However, in OCD, the dysfunctional caudate nucleus allows hyperactivity of the thalamus.
Receptors, which block serotonin from entering the cells, cause an imbalance and deficiency of neurotransmitter in essential areas of the brain. Serotonin imbalance may also be the cause of binge eating disorder. In binge eating, the activity of serotonin in the hypothalamus affects the hypothalamus’ ability to control appetite and food intake.
In ADHD, brain metabolism of dopamine is decreased in the areas of brain that control emotions, reactions, reasoning, concentration, attention, social judgement and movement. There are also signs of smaller brain size. Trauma to Pooh’s head causes his brain to strike the inside of his skull causing bruising, oedema and subdural haematoma, which may impair brain growth, leading to mental retardation.
haha... c'est la vie.. weird project.. but at least it was fun!
Inscribed @ 11:01 pm
-raison d'être-
Crimson Bisque
Seconded by her friends
Hooked after a few blogs
Doomed to express herself
every now and then
Crimson: red
Bisque: White unglazed porcelein
Crimson bisque:
A little rough around the edges,
rather fragile and stained red by the
change Jesus death and his blood
has brought about in my life
